Rising autism prevalence and longer wait times delay autism diagnosis
According to the CDC, 1 in 36 children in the U.S. are diagnosed with autism spectrum disorder (ASD). Even though ASD can be clinically diagnosed as early as 16 months old, the average age of diagnosis is currently 4 years of age. A biological, diagnostic tool can further inform clinical judgment and substantially improve early identification.
Breakthroughs in epigenetic research identify biomarkers to aid in autism diagnosis
Clarifi™️ ASD is a biological tool to aid in the diagnosis of autism based on epigenetics and the microbiome. Clarifi™️ ASD is not a genetic test. It is the product of scientific advancements in the area of epigenetics; the factors that influence how genes are turned on and off. Our peer-reviewed research discovered that certain RNA molecules that regulate gene activity and reflect interactions between a patient and their environment, were different in children with autism.
Published Research
- Saliva biomarkers of GI dysfunction in children with autism, Frontiers in Psychiatry, January 2022
- Longitudinal stability of salivary microRNA biomarkers in children and adolescents with autism spectrum disorder, Research in Autism Spectrum Disorder, April 2021
- Evidence-based use of scalable biomarkers to increase diagnostic efficiency and decrease lifetime costs of autism, Autism Research INSAR, March 2021
- Oral microbiota and autism spectrum disorder (ASD), Journal of Oral Microbiology, December 2019
- M14 – Combined analysis of the oral microbiome and microtranscriptome of autism spectrum disorder, Science Direct, March 2019
- Parent Perspectives Towards Genetic and Epigenetic Testing for Autism Spectrum Disorder, Journal of Autism and Developmental Disorders, March 2019
- Saliva microRNA Differentiates Children With Autism From Peers with Typical and Atypical Development, JAACAP, March 2019
- Validation of a Salivary RNA Test for Childhood Autism Spectrum Disorder, Frontiers in Genetics, November 2018
- Oral microbial activity may help identify autism in children, Healio Psychiatry, August 2018
- Diurnal Oscillations in Human Salivary microRNA and Microbial Transcription: Implications for Human Health and Disease, PLOS One July 2018
- A Comparative Review of microRNA Expression Patterns in Autism Spectrum Disorder, Frontiers in Psychiatry, November 2016
- Salivary MiRNA Profiles Identify Children with Autism Spectrum Disorder, Correlate with Adaptive Behavior, and Implicate ASD Candidate Genes Involved in Neurodevelopment, BMC Pediatrics April 2016
The Clarifi™ autism saliva test
Simple
Non-invasive and easily administered at-home saliva test.
Molecular
Measures epigenetic molecules in saliva.
Timely
Accelerates the diagnostic results in 3 to 6 weeks.
Objective
Based on peer-reviewed research.