Symptom scales to diagnose and manage concussion can be subjective

Test currently in validation phase

According to the (CDC), 1.6 to 3.8 million athletes will experience a sports-related mild traumatic brain injury (mTBI) or concussion each year. Despite increased public awareness, clinical guidelines still rely on subjective symptom scales to diagnose and manage concussions. Furthermore, there are currently no biological tests to diagnose mTBI.

Biomarkers found in saliva may distinguish mTBI and parallel symptom recovery

Research we are conducting in collaboration with Penn State College of Medicine and SUNY Upstate Medical University aims to change that. By analyzing brain derived biomarkers found in saliva, we have developed a novel diagnostic test for concussion. These biomarkers can confirm mTBI when run through our proprietary artificial intelligence platform.

Results of this research have been published in the journals JAMA Pediatrics, the International Journal of Molecular Sciences, and Clinical Translational Medicine.  In addition, we were recently awarded a $2.3 million grant from the NIH* to further the development of this saliva based test. 

This research is supported by the National Institutes of Health under Application Number 2 R42 MH111347-02A1 and does not necessarily represent the official views of the National Institutes of Health.

Published Research

Quadrant is actively involved in multiple research projects supporting the development of biomarkers for mTBI. We are currently looking for research collaborators interested in joining this effort.

If interested, please contact us through the link below