Variations in genetic codes may be the cause of ASD
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is believed to be caused by several different factors including but not limited to genes and their environment. Due to the wide spectrum of abilities and behavioral outcomes of those diagnosed with autism it is often hard to pinpoint whether or not the cause is related directly to a person’s genetics.
The American Academy of Pediatrics (AAP) recommends children with suspected Autism Spectrum Disorder (ASD), Global Developmental Delay (GDD) and Intellectual Disability (ID) should have genetic testing to determine the inherited cause of their condition.
Having a clear direction and understanding of diagnosis can save families time, money and stress when deciding what treatments and therapies can be most beneficial to the patient.¹
Genetic biomarkers may identify the cause
The Quadrant Laboratories’ Autism/XL-Intellectual Disability Test Panel targets genes that are associated with both syndromic and non-syndromic causes of autism spectrum disorder (ASD) and intellectual disabilities (ID). The ASD Panel is recommended if a specific underlying syndrome is not suspected. Using next-generation sequencing (NGS) we identify variants in the genetic code of the genes analyzed. Supplemental tests may include Sanger sequencing, Fragile X repeat expansion analyses, and Chromosomal Microarray testing. Variant classification and interpretation are performed based on the American College of Medical Genetics Standards and guidelines for the interpretation of sequence variants.
Benefits of Testing
If your child has been diagnosed with autism or an intellectual disability, our Autism/XL-Intellectual Disability Panel with the Fragile X repeat expansion may identify changes in the child’s genetic makeup that can give parents and healthcare providers insight into the potential cause of diagnosis.
This information can be used for:
- Therapeutic treatments
- Facilitate early detection of symptoms
- Inform family planning
- Carrier testing and genetic counseling
- Promote enrollment in clinical studies
Order a Genetic Test Panel (Prescription Only)
Our test requisition form includes options for single gene testing including the FMR1 gene for Fragile X Syndrome.
Have a patient that has been diagnosed with autism spectrum disorder on an intellectual disability? Request genetic testing to further assess their diagnosis.
There are two simple ways to order.
1. Submit a request through your Athena EMR System.
2. Complete the following forms and forward them to Quadrant Laboratories:
Your Health Care Providers must complete the test requisition form, informed consent, and letter of medical necessity forms on behalf of the patient, they may also complete the benefits investigation form.
Parents, guardians, or patients may complete the benefits investigation form if your doctor does not. Once the form is received and reviewed, a Quadrant Laboratories team member will contact you to discuss insurance coverage and financial responsibility (if any).
Send completed forms to:
Email: [email protected]
Fax: (315) 666-1379
Once all four forms are received and approved by Quadrant Laboratories an order will be placed,
and a saliva collection kit will be sent to the patient’s home.
Quadrant Laboratories performs genetic testing using a reference laboratory.