Variations in genetic codes may cause autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is believed to be caused by several different factors including but not limited to genes and their environment. Due to the wide spectrum of abilities and behavioral outcomes of those diagnosed with autism it is often hard to pinpoint whether or not the cause is related directly to a person's genetics.
The American Academy of Pediatrics (AAP) recommends children with suspected Autism Spectrum Disorder (ASD), Global Developmental Delay (GDD) and Intellectual Disability (ID) should have genetic testing to determine the inherited cause of their condition.
Having a clear direction and understanding of diagnosis can save families time, money and stress when deciding what treatments and therapies can be most beneficial to the patient.¹
Genetic biomarkers may identify the cause
The ASD Genetic Test Panel targets genes that are associated with both syndromic and non-syndromic causes of autism spectrum disorder (ASD). The ASD Panel is recommended if a specific underlying syndrome is not suspected. Using next-generation sequencing (NGS) we identify variants in the genetic code of the genes analyzed. Supplemental tests may include sanger sequencing, Fragile X repeat expansion analyses, and Chromosomal Microarray testing. Variant classification and interpretation are performed based on the American College of Medical Genetics Standards and guidelines for the interpretation of sequence variants.
Benefits of testing
If your child has been diagnosed with autism, the ASD Genetic Test Panel may identify changes in the child's genetic makeup that can give parents and healthcare providers insight into the potential cause of diagnosis.
This information can be used for:
- Therapeutic treatments
- Facilitate early detection of symptoms
- Inform family planning
- Carrier testing and genetic counseling
- Promote enrollment in clinical studies
|Sample Specimen||Collection Device||Billing Code(s)|
|Saliva||OCD-100||81301x1, 81304x1, 81321x1, 81323c1, 81403x2, 81404x6, 81405x13, 81406x16, 81407x8, 81408x1, 81479x293|
Quadrant Laboratories performs genetic testing using a reference laboratory.